Des[2′-(1H-tetrazol-5-yl)] 2-cyanolosartan; Losartan Cyano analog
Price : $155 – $355
CAS No. | : 114772-55-3 |
Mol F. | : C22H22ClN3O |
Mol W. | : 379.88 |
Cat No. | : SA26724 |
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Description
Product Name | Des[2′-(1H-tetrazol-5-yl)] 2-cyanolosartan |
Synonyms | 4’-[[2-Butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-[1,1’-biphenyl]-2-carbonitrile
2-Butyl-4-chloro-1-[(2’-cyanobiphenyl-4-yl)methyl]-5-hydroxymethylimidazole 4’-(2-Butyl-4-chloro-5-hydroxymethyl-1H-imidazol-1-yl)-1,1’-biphenyl-2-carbonitrile |
Related API | Losartan |
Category | Impurities |
Des[2′-(1H-tetrazol-5-yl)] 2-cyanolosartan product with CAS: 114772-55-3 is also known as 4’-[[2-Butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-[1,1’-biphenyl]-2-carbonitrile; 2-Butyl-4-chloro-1-[(2’-cyanobiphenyl-4-yl)methyl]-5-hydroxymethylimidazole. This product can be used as a working standard or secondary reference standard (additional internal validation as per respective FDA regulations/guidelines may require). Des[2′-(1H-tetrazol-5-yl)] 2-cyanolosartan is used in Losartan impurity profiling as per limits and threshold values specified by respective drug legislation, FDA, and pharmacopoeial guidelines during commercial production of Losartan and its related formulations. Moreover, 4’-[[2-Butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-[1,1’-biphenyl]-2-carbonitrile is also used in the process of Abbreviated New Drug Application (ANDA) filing to FDA and toxicity study of respective drug formulation. Please also find out other impurities of Losartan developed in our R&D.
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