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Ribociclib

Ribociclib Impurities

Ribociclib impurities include synthetic intermediates, process-related compounds, degradation products, and nitrosamine contaminants. These may arise during manufacturing, formulation, or long-term storage. As a CDK4/6 inhibitor used in the treatment of HR-positive, HER2-negative advanced breast cancer, impurity profiling is essential to ensure therapeutic safety, efficacy, and regulatory compliance. All impurity compounds are structurally characterized and qualified under ICH guidelines for toxicological evaluation and analytical validation.

Ribociclib EP Impurities

Pharmacopeial and non-pharmacopeial Ribociclib impurity compounds are available in compliance with European Pharmacopoeia (EP) specifications. These standards support analytical method development, impurity profiling, and stability testing. EP traceable materials are supplied with validated analytical data including purity, structural confirmation, and spectral characterization.

Ribociclib Related Compounds

Structurally related compounds and synthetic analogs associated with Ribociclib are included for use in impurity identification, toxicological qualification, and regulatory submission. These materials are thoroughly characterized and conform to international standards. Related compounds are used in forced degradation studies, genotoxicity assessments, and impurity threshold evaluations.

Ribociclib Impurity Reference Standards

Ribociclib impurity reference standards are provided with validated analytical data including purity, NMR, MS, and full Certificates of Analysis. These standards are used in pharmaceutical research, method validation, and GMP-compliant quality control. EP/USP traceable entries are available upon request and are routinely re-tested to ensure consistency and reliability.

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CAS No.

: 1374639-77-6

Mol F.

: C12H14ClN3O

Mol W.

: 251.71

Cat No.

: SA47124

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CAS No.

: 120613-50-5

Mol F.

: C10H6Cl2N4O

Mol W.

: 269.1

Cat No.

: SA47117

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CAS No.

: NA

Mol F.

: C23H30N8O2

Mol W.

: 450.54

Cat No.

: SA47120

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CAS No.

: NA

Mol F.

: C26H30ClN7O2

Mol W.

: 508

Cat No.

: SA47113

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CAS No.

: 2460738-27-4

Mol F.

: C21H28N8O

Mol W.

: 408.5

Cat No.

: SA47101

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CAS No.

: 2069953-39-3

Mol F.

: C23H30N8O2

Mol W.

: 450.55

Cat No.

: SA47119

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CAS No.

: 2481084-18-6

Mol F.

: C9H11Br2N3

Mol W.

: 321

Cat No.

: SA47112

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CAS No.

: 1214279-37-4

Mol F.

: C9H11Cl2N3

Mol W.

: 232.1

Cat No.

: SA47111

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CAS No.

: NA

Mol F.

: C24H27ClN6O2

Mol W.

: 467

Cat No.

: SA47114

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CAS No.

: NA

Mol F.

: C24H27ClN6O2

Mol W.

: 467

Cat No.

: SA47116

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CAS No.

: 1374639-76-5

Mol F.

: C12H14ClN3O

Mol W.

: 251.7

Cat No.

: SA47123

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CAS No.

: NA

Mol F.

: C15H17N3O2

Mol W.

: 271.3

Cat No.

: SA47115

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CAS No.

: 3060653-14-4

Mol F.

: C27H34N8O4

Mol W.

: 534.6

Cat No.

: SA47122

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CAS No.

: 1823404-28-9

Mol F.

: C9H11BrClN3

Mol W.

: 276.56

Cat No.

: SA47110

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CAS No.

: 3027550-95-1

Mol F.

: C23H30N8O2

Mol W.

: 450.55

Cat No.

: SA47103

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CAS No.

: 3027550-94-0

Mol F.

: C23H30N8O3

Mol W.

: 466.55

Cat No.

: SA47100

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CAS No.

: 3027550-96-2

Mol F.

: C22H28N8O2

Mol W.

: 436.52

Cat No.

: SA47106

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CAS No.

: 2460732-08-3

Mol F.

: C24H30N8O2

Mol W.

: 462.56

Cat No.

: SA47105

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CAS No.

: 2514753-27-4

Mol F.

: C23H30N8O2

Mol W.

: 450.54

Cat No.

: SA47118

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CAS No.

: 2460734-07-8

Mol F.

: C23H30N8O2

Mol W.

: 450.55

Cat No.

: SA47102

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CAS No.

: NA

Mol F.

: C23H28N10O3

Mol W.

: 492.5

Cat No.

: SA47109

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CAS No.

: NA

Mol F.

: C23H29N9O2

Mol W.

: 463.5

Cat No.

: SA47108

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CAS No.

: 3027550-97-3

Mol F.

: C22H27N7O2

Mol W.

: 421.51

Cat No.

: SA47107

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CAS No.

: 1211441-59-6

Mol F.

: C22H28N8O

Mol W.

: 420.52

Cat No.

: SA47104

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CAS No.

: 571189-16-7

Mol F.

: C14H20N4O4

Mol W.

: 308.3

Cat No.

: SA47127

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CAS No.

: 39856-50-3

Mol F.

: C5H3BrN2O2

Mol W.

: 203.0

Cat No.

: SA47126

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CAS No.

: 52092-47-4

Mol F.

: C5H3ClN2O2

Mol W.

: 158.54

Cat No.

: SA47128

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CAS No.

: NA

Mol F.

: C21H26N8O

Mol W.

: 406

Cat No.

: SA47121

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CAS No.

: 1211443-58-1

Mol F.

: C12H12ClN3O2

Mol W.

: 265.7

Cat No.

: SA47125

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