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Baricitinib

Baricitinib Impurities

Baricitinib impurities include synthetic intermediates, process-related compounds, degradation products, and residual solvents that may arise during synthesis, formulation, or storage. As a selective Janus kinase (JAK) inhibitor used in the treatment of rheumatoid arthritis, alopecia areata, and COVID-19-related inflammation, impurity profiling is essential to ensure product safety, therapeutic efficacy, and regulatory compliance. Known degradation pathways include hydrolysis and oxidative cleavage of the nitrile and pyrazole moieties under stress conditions. All impurity compounds are structurally characterized and qualified under ICH guidelines for toxicological evaluation and analytical validation.

Baricitinib EP Impurities

Pharmacopeial and non-pharmacopeial Baricitinib impurity compounds are available in compliance with European Pharmacopoeia (EP) specifications. These standards support analytical method development, impurity profiling, and stability testing. EP traceable materials are supplied with validated analytical data including purity, structural confirmation, and spectral characterization.

Baricitinib Related Compounds

Structurally related compounds and synthetic analogs associated with Baricitinib are included for use in impurity identification, toxicological qualification, and regulatory submission. These materials are thoroughly characterized and conform to international standards. Related compounds are used in forced degradation studies, genotoxicity assessments, and impurity threshold evaluations.

Baricitinib Impurity Reference Standards

Baricitinib impurity reference standards are provided with validated analytical data including purity, NMR, MS, and full Certificates of Analysis. These standards are used in pharmaceutical research, method validation, and GMP-compliant quality control. EP/USP traceable entries are available upon request and are routinely re-tested to ensure consistency and reliability.

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CAS No.

: 1187594-09-7

Mol F.

: C16H17N7O2S

Mol W.

: 371.4

Cat No.

: SA56400

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CAS No.

: 2271228-51-2

Mol F.

: C16H19N7O3S

Mol W.

: 389.4

Cat No.

: SA56406

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CAS No.

: 2271228-52-3

Mol F.

: C16H18N6O4S

Mol W.

: 390.4

Cat No.

: SA56409

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CAS No.

: 1187594-35-9

Mol F.

: C18H21N7O2S

Mol W.

: 399.5

Cat No.

: SA56405

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CAS No.

: 1187594-16-6

Mol F.

: C14H13N7

Mol W.

: 279.3

Cat No.

: SA56408

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CAS No.

: 1187595-85-2

Mol F.

: C7H10N2O2S

Mol W.

: 186.2

Cat No.

: SA56401

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CAS No.

: 3680-69-1

Mol F.

: C6H4ClN3

Mol W.

: 153.6

Cat No.

: SA56402

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CAS No.

: 2055723-13-0

Mol F.

: C21H25N7O4S

Mol W.

: 471.5

Cat No.

: SA56403

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CAS No.

: 2402776-80-9

Mol F.

: C17H20N6O4S

Mol W.

: 404.4

Cat No.

: SA56407

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CAS No.

: 1187594-34-8

Mol F.

: C17H19N7O2S

Mol W.

: 385.4

Cat No.

: SA56411

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CAS No.

: 3680-71-5

Mol F.

: C6H5N3O

Mol W.

: 135.1

Cat No.

: SA56404

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CAS No.

: 1187595-89-6

Mol F.

: C17H19N7O3S

Mol W.

: 401.5

Cat No.

: SA56410

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